About Nikolic Lab

About the Nikolic Lab:

 

Nikolic Lab, based in Calgary, Alberta, is a leading research group dedicated to advancing the understanding of glioblastoma (GBM) epigenetics and cellular state plasticity. We are committed to conducting cutting-edge research while fostering a collaborative and innovative scientific environment.

 

Glioblastoma (GBM) is the most common and aggressive form of primary brain cancer in adults. Despite current standard-of-care treatments (which typically include surgical resection, chemotherapy, and radiation), patient outcomes remain poor, with a median survival time of approximately 14 months. Tumor recurrence is almost inevitable, and there are currently no effective methods for prevention.

 

Our research seeks to uncover the fundamental mechanisms underlying both primary tumor formation and recurrence in GBM. We investigate how tumor cells emerge, adapt, and resist therapy, with a particular focus on the spatial and temporal dynamics of tumor evolution. By examining how cellular states change across different regions of the tumor and over time (before, during, and after treatment), we aim to identify the epigenetic and cellular factors that drive tumorigenesis and therapeutic failure. These insights will inform the development of more effective, durable treatment strategies.

 

Through this website, we aim to present our research priorities, showcase current projects, and offer a deeper understanding of our scientific direction. We welcome fellow researchers, potential collaborators, and all those with an interest in glioblastoma biology to discover the focus areas of our research and share in the ongoing pursuit of understanding GBM biology.